|
KMID : 0352720160400030285
|
|
Journal of Ginseng Research
2016 Volume.40 No. 3 p.285 ~ p.291
|
|
|
Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways
|
|
Na Qin
Wei Yang
Dongxu Feng
Xinwen Wang
Muyao Qi
Tianxin Du
Hongzhi Sun
Shufang Wu
|
|
|
Abstract
|
|
|
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary hypertension and to elucidate the underlying mechanism.
Methods: MCT-intoxicated rats were treated with gradient doses of TG, with or without NG-nitro-Larginine methyl ester. The levels of molecules involving the regulation of nitric oxide and mitogenactivated protein kinase pathways were determined.
Results: TG ameliorated MCT-induced pulmonary hypertension in a dose-dependent manner, as assessed by the right ventricular systolic pressure, the right ventricular hypertrophy index, and pulmonary arterial remodeling. Furthermore, TG increased the levels of pulmonary nitric oxide, endothelial nitric oxide synthase, and cyclic guanosine monophosphate. Lastly, TG increased mitogen-activated protein kinase phosphatase-1 expression and promoted the dephosphorylation of extracellular signal-regulated protein kinases 1/2, p38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase 1/2.
Conclusion: TG attenuates MCT-induced pulmonary hypertension, which may involve in part the regulation of nitric oxide and mitogen-activated protein kinase pathways.
|
|
|
KEYWORD
|
|
|
endothelial nitric oxide synthase, mitogen-activated protein kinases, nitric oxide, pulmonary hypertension, total ginsenoside
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|